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INTRODUCTION

Sitasoft-M500 is an oral medication designed to improve blood sugar control in adults with type 2 diabetes mellitus. It combines the benefits of Sitagliptin and Metformin to enhance insulin production, reduce glucose production in the liver, and improve the body’s response to insulin. This dual-action formula helps to maintain healthy blood sugar levels when used alongside a proper diet and exercise regimen.

COMPOSITION

Sitasoft-M500 combines two active ingredients, Sitagliptin and Metformin, each playing a unique role in blood sugar management:

• Sitagliptin (50mg): Sitagliptin belongs to a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by increasing the levels of incretin hormones, which help to regulate insulin production after eating. Sitagliptin also helps to lower the amount of glucose produced by the liver, making it easier to maintain normal blood sugar levels.
• Metformin (500mg): Metformin is a biguanide that improves insulin sensitivity and decreases glucose production in the liver. It also reduces the absorption of glucose in the intestines. By enhancing the body’s response to insulin, Metformin helps to keep blood sugar levels under control, making it a cornerstone of diabetes management.

INDICATIONS

Sitasoft-M500 is indicated for the treatment of type 2 diabetes mellitus in adults. It is prescribed when diet and exercise alone are insufficient to control blood sugar levels. This medication helps to prevent serious complications of diabetes, such as kidney damage and blindness. Sitasoft-M500 is to be used in combination with a healthy diet and regular exercise to improve blood sugar control.

HOW IT WORKS

Sitagliptin is a DPP-4 inhibitor that works by increasing the levels of incretin hormones, which help regulate insulin production after eating. Incretin hormones stimulate the release of insulin from the pancreas in response to meals and decrease the amount of glucose produced by the liver. By inhibiting the enzyme DPP-4, Sitagliptin prolongs the activity of these hormones, thereby enhancing their beneficial effects on blood sugar control. This results in better post-meal and overall blood sugar levels.

Metformin is a biguanide that works through multiple mechanisms. It primarily reduces glucose production in the liver, which is a significant source of high blood sugar levels in people with diabetes. Metformin also improves the body’s sensitivity to insulin, allowing cells to take up and use glucose more effectively. Additionally, Metformin decreases the absorption of glucose in the intestines, which helps to further reduce blood sugar levels after meals.

SAFETY ADVICE

• Take Sitasoft-M500 as prescribed by your doctor. Do not chew, crush, or break the tablet; swallow it whole with a glass of water.
• Monitor your blood sugar levels regularly while taking this medication.
• Limit alcohol intake, as it can increase the risk of developing low blood sugar levels.
• Inform your doctor if you have a history of kidney disease, heart or pancreas problems.
• Pregnant or breastfeeding women should consult their doctor before taking Sitasoft-M500.
• Report any severe side effects or allergic reactions to your doctor immediately.

DRUG INTERACTIONS

Sitasoft-M500 may interact with other medications, including:

• Sulfonylureas or insulin (other diabetes medications)
• Ketoconazole and itraconazole (antifungal medications)
• Ritonavir (antiviral medication)

SIDE EFFECTS

Common side effects of Sitasoft-M500 may include:

• Headache
• Nasopharyngitis (inflammation of the throat and nasal passages)
• Hypoglycemia (low blood glucose level)
• Upper respiratory tract infections
• Gastrointestinal discomfort (nausea, vomiting, diarrhea)

STORAGE INSTRUCTIONS

Store below 30°C.